Six Sigma started in the manufacturing industry and proved its existence in every other industry over the years. Now speaking of the healthcare industry which every person on the earth relies on, six sigma does prove its worth for the better life of its users (us). The Covid-19 has stopped us from all the plans, activities, and normal life we had. This has been the ultimate inconvenience for people where covid didn't stop just there, costing millions of lives for the past year. This threat has put a lot of pressure on the researchers to find a vaccine that will save the lives on his earth. Here comes the question of how six sigma plays its part in finding a vaccine for this deadliest disease? This article will shed light on its contribution to vaccine research. To find a vaccine there requires a lot of research to be done in advance for the people to trust and take the vaccine. Finding one without any proper research will create chaos among the people again. So for the research gre